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Are Chantix and Wellbutrin the same? Wellbutrin (bupropion) is an antidepressant used for the management of major depression and seasonal affective disorder and Chantix (varenicline) is used for cessation of smoking. The Zyban brand of bupropion is used similarly to Chantix to help people stop smoking by reducing cravings and other withdrawal effects.
What does Chantix do to the brain? Chantix works on two levels. First, it partially activates sites in the brain known as nicotinic acetylcholine receptors that are affected by nicotine. Second, Chantix has the unique ability to stop nicotine from attaching to those nicotine receptors if you smoke while using it.
How does Champix affect your brain? Using Varenicline (Champix) to Quit Smoking. The precise action of varenicline is that it interferes with the receptors in the brain that nicotine stimulates. (The nicotine in cigarettes attaches to receptors in brain cells to stimulate part of the brain — this is how nicotine has its effect.)
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