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What is the difference between memantine and donepezil? Memantine and donepezil combination is used to treat dementia (memory loss and mental changes) associated with moderate or severe Alzheimer's disease. Memantine and donepezil will not cure Alzheimer's disease, however, it may improve thinking ability, behavior, or functional ability. Why is memantine prescribed? Memantine is used to treat the symptoms of Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Memantine is in a class of medications called NMDA receptor antagonists. It works by decreasing abnormal activity in the brain. Can memantine cause memory problems? Memantine and donepezil combination is used to treat dementia (memory loss and mental changes) associated with moderate or severe Alzheimer's disease. Memantine and donepezil will not cure Alzheimer's disease, however, it may improve thinking ability, behavior, or functional ability. Does donepezil need to be taken with food? Donepezil should be taken at bedtime unless otherwise directed by your doctor. It may be taken with or without food, on a full or empty stomach. Swallow the tablet whole. Do not crush, break, or chew it. Is memantine better than Aricept? The effects of memantine should be compared to those of donepezil, which is the most prescribed anticholinesterase drug. Memantine Versus Donepezil in Early Stages of Alzheimer's Disease. Condition or disease Intervention/treatment Phase Dementia, Alzheimer Type Drug: Memantine Drug: Donepezil Phase 4 Does dementia affect appetite? Many people with dementia experience sudden changes in appetite preferences and an increase in unhealthy cravings. As the disease progresses, taste buds diminish, insulin in the brain can drop and some people experience intense cravings for high-calorie foods.
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