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What causes adrenal hyperplasia? Congenital adrenal hyperplasia is an inherited condition caused by mutations in genes that code for enzymes involved in making steroid hormones in the adrenal glands. The most common enzyme defect, 21-hydroxylase deficiency, leads to excess amounts of male hormones being produced by the adrenal glands.
What does Congenital Adrenal Hyperplasia mean? Congenital adrenal hyperplasia, also called CAH, is a group of genetic disorders in which the two adrenal glands do not work properly. People with CAH lack one of the enzymes (proteins that cause chemical changes in the body), steroid 21-hydroxylase.
Is congenital adrenal hyperplasia curable? Although there is no cure, with proper treatment, most people with congenital adrenal hyperplasia can lead normal lives.
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